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Ideally, heterogeneous genetic and residual variances should be modeled simultaneously, for example with multiple breed studies (de Roos et al. 2009) or genotype by environment interaction (Edwards and Jannink 2006; Jarquin et al. 2014; Lopez Cruz et al. 2015) studies, both of which require the specification of heterogeneous genetic variances.
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Therefore, camel breed study could help their conservation and support camel pastoralists (Kakar et al. 2011).
When the breed studied has a reduced intra-breed diversity, the combination of dogs from international locations does not increase the rate of false positives and potentially increases the power of association studies.
The clinical phenotype of BSE in the genotypes and breed studied was indistinguishable from that described for classical scrapie cases.
As expected from SNP and sequence data [ 1, 3], Boxers were the least diverse breed studied and Border Collies were the most diverse breed (Table 3).
All were purebred: French bulldogs were the commonest breed studied and accounted for 29 of the 50 cases (58%), while other breeds evaluated included English bulldogs (n = 8, 16%), Pug (n =���12, 24%) and Shih-tzu (n = 1, 2%).
Of interest, a subset of the EASZ calves has European taurine ancestry, while the other East African cattle breed studied, the Sheko, shows no European taurine introgression (Supplementary Table S1).
As found in the Danish breed study from 2008, the seizure type was predominantly (83%% of dogs) defined as focal or focal epileptic seizures evolving into generalised seizures, while only 6%% of dogs experienced (primary) generalised epileptic seizures [ 41].
Finally, we observed that, for each breed studied, it was possible to define specific haplotypes for a number of OR genes characteristic of the breed, which could be used as a genetic signature to determine whether or not a particular dog belongs to a particular breed.
However, most multi-breed studies assume that marker effects are the same across populations [ 6, 8- 10].
Among the 14 B. indicus cattle breeds studied, a total of 19 polymorphic sites were identified: 4 in the 5′-UTR and 15 in the coding region (of these 2 were non-synonymous).
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