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These predictions would likely primarily comprise two to three breed predictions (Angus or Red Angus and a Continental breed), and could set the stage for implementation in populations with higher amounts of admixture and unknown but highly variable breed composition.
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Previous studies based on Single Nucleotide Polymorphism (SNP) markers from the Illumina 50K SNP chip [ 8] have reported that distances between markers would be too large for high persistence of linkage disequilibrium (LD) phase across breeds, and accuracies of across breed prediction were zero [ 9, 10].
Results from [ 31, 32] suggest that across-breed predictions in animal breeding are favorable when populations are closely related, marker density is high and within-breed training populations are small.
Here, we show the advantages of nonlinear genomic prediction methods with across-breed predictions.
Across-breed predictions showed an overall benefit of using BayesR compared to GBLUP (Table 5).
As expected, empirical cross-breed predictions in cattle fell to zero using 50 K SNPs, although combining breeds into a single training set resulted in prediction accuracies comparable to within-breed predictions [ 13].
In contrast, accuracies for the American Limousin population from within-breed predictions were equal to ∼0.4, and for yearling weight, they even reached 0.76 [ 26].
Studies on beef cattle across-breed predictions are limited [ 14, 15], but accuracies of g.CIMF and g.WW reported here were in the same range than those in [ 15].
The presence of large-effect QTL that do not segregate in all breeds is a significant limitation in multi-breed predictions.
However, it might prove useful in across-breed predictions, if training data are available on both breeds and the focus is on prediction accuracy in a given breed.
Across various traits and breed combinations, BayesR outperformed GBLUP by on average 7% for all across-breed predictions in milk production traits.
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