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We developed a modified multiple breath nitrogen washout method for FRC measurement that relies on end-tidal gas fractions and alveolar tidal volume measurements as inputs but does not require the traditional measurements of volume of nitrogen or oxygen.
multiple breath nitrogen washout.
Multiple breath nitrogen (N2) washout (MBNW) is a non-invasive approach in the quantitative assessment of ventilation heterogeneity [71 79].
End-expiratory lung volume was measured at baseline IAP and PEEP of 5 cmH2O using the multiple breath nitrogen wash-out method as previously described [11].
Single breath nitrogen washout [ 45 ].
See the Additional file 2: Figure S2 for the single breath nitrogen washout test curve.
Similar(48)
The slope of phase III of the single-breath nitrogen (N2) test detects smoking-induced alterations in smokers before spirometry is impaired.
Obstruction of peripheral airways, as assessed by the slope of phase III of the single-breath nitrogen (N2) test, is associated with some cough symptoms independently of spirometric results and in addition to smoking history.
The slope of phase III of the single-breath nitrogen (N2) test (slope of phase III) is more sensitive than spirometry in detecting obstruction of peripheral airways in smokers.
Traditionally, EELV measurement techniques are based on dilution of tracer gases, such as sulfur hexafluoride washout [ 4], closed circuit helium dilution [ 5], or open circuit multi-breath nitrogen washout [ 6].
Simulations of inert gas asphyxiation (in which no oxygen at all was present) conducted by The International Humanitarian Hypoxia Project, show that "after just two or three breaths of nitrogen, the oxygen concentration in the lungs would be low enough for some oxygen already in the bloodstream to exchange back to the lungs and be eliminated by exhalation".
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