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Two colorectal cancer trials (Nottingham and Goteborg) and one breast cancer trial (Two-County: Ostergotland) provided these data.
We found information on interval cancers and screen detected cancers in both arms of the Gothenburg Breast Screening Trial [ 11] and the Swedish two-county trial [ 12].
Herein we have identified and validated a genetic biomarker for bevacizumab-induced hypertension in the adjuvant breast cancer trial, ECOG-5103 (whose efficacy data were not yet available for this analysis) and the metastatic breast cancer trial, ECOG-2100.
But the breast cancer trial showed the way, cancer experts said.
They also said the progression-free survival was a more practical goal for a breast cancer trial.
The breast cancer trial, the Study of Tamoxifen and Raloxifene, or STAR, has been a focus of intense debate.
In fact, a breast cancer trial called I-SPY 2, already under way, may be a good model to follow.
Re "New Drug Regimen Greatly Cuts Risk of Recurring Breast Cancer" (front page, Oct. 10) and "Halting a Breast Cancer Trial" (editorial, Oct. 12): All of us should be pleased that the researchers found a balance between rigid experiment standards and compassion.
The Cairo Breast Screening Trial (CBST) was designed to evaluate the role of clinical breast examination as a primary screening modality in the context of primary care, as in Egypt breast cancer is usually diagnosed at an advanced stage.
The Cambridge Breast IMRT trial had as primary end point photographic assessment of late cosmetic effects.
Toxicity profile was similar to that reported from the breast cancer trial.
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