Sentence examples for breast spheres from inspiring English sources
As Figure 5(b) showed, the formation of breast spheres in MCF7 and SUM159 cells was inhibited.
Similar trend was observed in the microenvironment of breast cancer spheres when compared to HMEC spheres (Additional file 1: Figure S1).
IAK-1/Aurora A, Bub1, BubR1 and Mps1 aneuploid kinase levels were upregulated in breast cancer spheres when compared to HMEC spheres (Fig. 8c).
The milieu of the breast cancer spheres seems highly active with new cells colonizing around and homing onto the bigger spheres when compared to HMEC spheres.
Breast cancer spheres were also generated from SUM149PT and SUM1315MO2 cells and cultured for three generations.
The differences in morphology and branching of breast cancer spheres indicated a very dynamic microenvironment and highlighted the complexity of the disease.
Since increased proliferation could be attributed to the activation of cell survival kinases, we compared the phosphorylated and total levels of survival kinases such as AKT, p44/42, p65 and GSK3β in HMEC and breast cancer spheres (Fig. 9a).
To determine factors that may induce aneuploidy, we tested the basal levels of IAK-1/Aurora A, Bub1, BubR1 and Mps1 aneuploidy kinases in HMEC and breast cancer spheres (Fig. 8c).
Breast cancer sphere images clearly demonstrate the adherence of multiple spheres forming bigger size spheres.
Thus, these set of experiments highlighted the importance of PEA15 and its phosphorylation at Ser in breast cancer sphere formation.
Breast cancer-derived sphere cells exhibit higher resistance to radiation and chemotherapy [14], [15], [16], and greater tumorigenic potential [17], [18].
