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The transcription factor MYB is an oncogene in human leukemias, and in epithelial cancers of the colon and breast (reviewed in [ 14, 15]).
Interestingly, in 1982, Nusse and Varmus (1982) identified the first Wnt gene as being a mammary oncogene, and several members of the Wnt family have been linked to cancer development, especially of the breast (reviewed in Li et al, 2000).
In relation to cancer cell growth, mifepristone was shown to have antiproliferative effects in cervical [ 7], breast (reviewed in [ 8]), endometrial [ 9- 12], ovarian [ 13- 17], gastric [ 18] and prostate cancer cells [ 19, 20].
BRCA1 and BRCA2 gene carriers are at increased risk of developing contralateral breast cancer and appear, in the longer term, to have an increased rate of new primary tumours in the affected breast (reviewed in[ 22]).
In vivo studies have supported a role for progesterone in the induction of cyclic proliferation in the breast (reviewed in Graham and Clarke, 1997), although they were not consistent with clinical trials that found that percutaneous progesterone acts as an inhibitor of oestrogen-induced proliferation (Chang et al, 1995; Foidart et al, 1998).
Similar(55)
This article introduces H-MRS of the breast, reviews the literature, discusses current methods and technical issues, and describes applications for treatment monitoring and lesion diagnosis.
Several genes have previously been shown to be aberrantly methylated in breast cancer (reviewed in [22]).
Likewise, Epstein Barr virus (EBV), human herpes virus-8 (HHV-8) and bovine leukemia virus (BLV) have been detected in breast tumors, reviewed in [45].
14 Dedicated breast radiologists reviewed MRI and mammographic images.
Eight surgical oncologists who specialized in breast cancer reviewed all available survival data for this study.
Several genes have been previously reported to be aberrantly methylated in breast cancer (reviewed in [ 32- 34]).
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