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Subcutaneous implantation of DESCLAYMR_DOX in athymic mice resulted in significant growth inhibition of human tumor xenografts of breast origin and decelerated multi-organ metastasis formation.
In women, mammography is indicated when appropriate immunohistochemistry confirms breast origin; if the mammogram is non-diagnostic and there is histopathological evidence of breast cancer, breast ultrasound and/or magnetic resonance imaging (MRI) should be suggested [31].
Although the breast origin of this human cell line is controversial and currently under scrutiny [49], [50], these cancer cells are a high integrin αvβ3 expressor and thus constitute a good model for screening pharmacological inhibitors directed at this receptor.
In the last decades, PIP protein expression has been proposed as a specific and sensitive marker for breast cancer [4] [7] and further used to support breast origin in metastatic carcinoma of unknown primary origin [8] [12].
We repeated these experiments in two cell lines of breast origin.
The immunostaining profile and tumor morphology were consistent with a metastatic carcinoma of breast origin.
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However, information about the risk of third cancer of non-breast origin (third non-breast cancer; TNBC) after synchronous or metachronous invasive bilateral breast cancer (BBC) is lacking.
This study examined the risk of third cancer of non-breast origin (TNBC) among women with bilateral breast cancer (BBC; either synchronous or metachronous), focussing on the relation with breast cancer treatment.
Further experiments confirmed that BORIS could activate promoters of both ER and PR genes in the reporter assays in cells of breast and non-breast origin; thus, pointing at the possible molecular mechanism of direct transcriptional regulation of these genes.
One of the main finding is that AP-2 transcription factors are probably not involved in the increase in erbB-2 transcript levels in tumours of non-breast origins.
However, as reviewed in [ 37], both cell lines may be of MDA-MB-435 breast cancer origin rather than of melanoma origin due to the following rationale.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com