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The breast microenvironment can either retard or accelerate the events associated with progression of latent cancers.
Adipose tissue is known to contain active endocrine cells that may contribute to perturbations in the breast microenvironment [ 67, 68].
This may suggest heterogeneity among patients or the effects of parity on the breast microenvironment being transient.
There is good evidence that during involution, which is initiated by weaning, the breast microenvironment becomes tumor promotional [ 6].
We evaluated the potential role of GPER and related signaling in E2 production in the breast microenvironment.
The Active subtype of breast microenvironment is correlated with TWIST-overexpression signatures and shares features of claudin-low breast cancers.
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NPs also have been applied in the microfluidic 3D tumor model ("Tumor microenvironment-on-chip") reconstituting the breast cancer microenvironment surrounded by the lymphatic and capillary microvessels (Fig. 3b) [77].
We hypothesized that gene expression subtypes of breast cancer microenvironment can be defined and that these microenvironment subtypes have clinical relevance.
Figure 3 Hypothesis for the protumorigenic role of UA in the breast cancer microenvironment.
Together, these findings support the hypothesis that hyperuricemia might be partially responsible for the low grade inflammation present in the breast tumor microenvironment that contributes to tumor cell proliferation and metastasis.
These observations revealed the CAF-dependent estrogenic effects on breast cancer microenvironment.
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