The top five biological functions of PP-DMR included organ development, tissue development, cellular development, nervous system development and function and organismal development (Fig. S10 ).
ERα plays an important role in the proliferation and progression of breast cancer, whereas a distinct function of ERβ in breast cancer initiation and development has not yet been clearly established.
Based on these findings, it is possible to propose the hypothesis that some of the breast cancer-specific targets of estrogen signaling may function as early premalignant changes in the process that leads to breast cancer initiation and development.
Owing partly to a lack of appropriate models, much of our current understanding of normal breast development derives from studies in animals and, remarkably, details of how the normal human breast functions remain largely unknown.
Progesterone receptor is a fundamental orchestrator of breast development and function [29], but is also implicated in breast cancer development and progression, although its role in these processes is still to be fully established [1].
The top 5 physiological system development and functions included: tissue development, skeletal and muscular system development, cardiovascular system development and function, organismal development, and hematological system development.
Breast development is a component of puberty, occurring in the continuum of the development of gonadal function and the ontogeny of the hypothalamic pituitary gonadal axis, beginning in the fetus and continuing until adulthood (Grumbach 2002).
Overall, CYP1B1 has a variety of functions in both the treatment and development of breast cancer.
Several data indicate that AKAP9 is involved in striated muscle and synapse functioning, in development of breast and thyroid cancers, and in spermatogenesis [ 18, 21].
Breast cancer development and progression are dependent on estrogen activity.
