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This analysis examined the radiation dose distribution delivered to the anatomically defined axillary level I and II lymph node volume and surgically placed axillary clips with conventional tangential breast fields and CT-based three-dimensional (3D) planning.
Background and purpose: To develop a method of using a multileaf collimator (MLC) to deliver intensity modulated radiotherapy (IMRT) for tangential breast fields, using an MLC to deliver a set of multiple static fields (MSFs).
Second cancer sites were grouped according to doses received from typical tangential breast fields.
A MHD less than 1 cm and a CLD less than 2 cm are the criteria used for planning tangential breast fields to minimise heart and lung morbidity.
We observed that girls from valley towns, areas using modern agricultural practices, exhibited larger breast fields than those of girls living in the foothills who exhibited similar stature [e.g., weight, height, body mass index (BMI)], and genetic background.
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Girls were staged as prepubescent if no mammary budding could be observed or palpated in the breast field.
Measurements were made by palpation of the diameter of firm, internal, mammary tissue as well as the diameter of the softer, external breast field.
Genomic alterations in DCIS lesions could be informative of outcome by being markers of a certain relationship between the malignant cells and the tumour microenvironment permissive to local recurrence or by reflecting the genetic instability of the local breast field.
Although molecular analyses of peritumoral tissues are providing evidence for breast field effects (the presence of larger areas of molecular alteration surrounding histologically confirmed breast cancer foci), epidemiological data inter-relating breast cancer risk factors, breast cancer subtypes and characteristics of benign tissues surrounding cancers are limited.
All CVD patients had received left-sided radiotherapy (9 of 71) at a mean age of 65 years, and in all but one (8 of 9) the heart was within the tangential breast field (mean MHD=1.9 cm, median=0.56 and range 0 3.5 cm).
We have previously shown that modified breast tangent fields can include most axillary Level I-II lymph nodes.
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