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However, breast development may be associated with light pubic hair development in a few of these cases.
However, assessment of breast development may be confounded by increased body weight and failure to distinguish between increased adiposity and breast bud development, yielding misleading conclusions about the onset of puberty (Walvoord, 2010).
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This suggests that breast duct development may be a period of raised susceptibility to breast carcinogenesis, and that the association between puberty and breast cancer is complex and not best represented by a single event.
Although the mechanisms are not elucidated, menopausal effects on the role of MBD2 in breast cancer development may be related to changes in sex hormone levels.
Breast duct development may be a time of heightened susceptibility to risk of carcinogenesis, and greater attention needs to be given to the relation of breast cancer risk to the different stages of puberty.
Variation in phenotypic expression including some breast and uterine development may be due to partial aromatase activity.
Animal experiments indicate that puberty and early development may be the period during which the breast is most sensitive to these effects (Fenton 2006).
Symmetrical breast development may well be an indicator of an individual's ability to tolerate 'disruptive' hormonal variation whilst maintaining developmental stability.
Pin1 plays a pivotal role in breast development and may be a promising new anticancer target.
These findings suggest a dichotomous role for NURR1 in breast cancer development which may be substantially impacted by the cellular context under which the receptor is expressed.
Since there is evidence that ERβ can modulate the activity of ERα under some circumstances [ 64], it is possible that normal breast development as well as breast cancer progression may be accompanied by changes in the ratios of these two receptors [ 8].
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