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Progesterone receptor is a fundamental orchestrator of breast development and function [29], but is also implicated in breast cancer development and progression, although its role in these processes is still to be fully established [1].
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PTHrP thus has important functions in normal breast development and physiology.
By regulating genes controlling cell cycle arrest, apoptosis, EMT, migration, invasion, and metastasis formation, Smads have crucial functions in both breast development and breast cancer.
Estrogen and progesterone play leading roles in orchestrating proper development and function of breast tissue.
PTHrP is expressed in breast epithelium and participates in normal mammary gland development and function.
E2 is the predominant form driving sexual development and function of reproductive organs (e.g., breast and uterus) and the menstrual cycle.
The benefits of this sea green extend far beyond basic nutrition: Research suggests seaweed can also help regulate estrogen and estradiol levels -- two hormones responsible for proper development and function of sexual organs -- potentially reducing the risk of breast cancer.
TGF-β is an important regulator of normal mammary gland development and function, as well as of the development and progression of breast tumors.
Neurotrophin regulation of neural circuit development and function.
6. Mast cell development and function.
2. NKT cell development and function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com