Histopathological examination of the breast capsule revealed none specific inflammatory changes without identifying any germ.
Breast capsule samples were collected at the time of implant removal in patients undergoing breast implant replacement or revision surgery.
The continued activity of fibroblasts and myofibroblasts in a breast capsule may result in highly aligned fibers and a rigid collagen capsule [ 4].
Recently, findings of silicone-induced granuloma have been reported in the breast implant capsule, termed silicone-induced granuloma of the breast implant capsule (SIGBIC) [6].
Consistent with our speculation, our recent study has revealed that protease-degraded collagen I fragments of the breast tumor capsule function as a specific mediator to attract macrophage and other immune cell infiltration [ 34].
Cheriyan T, Guo L, Orgill DP, Padera RF, Schmid TM, Spector M. Lubricin in human breast tissue expander capsules.
Pajkos et al. reported growth from 24/48 (50%) breast implant and/or capsule samples studied; 17/19 samples from patients with capsular contracture were culture positive (mostly for coagulase-negative staphylococci), compared with only 1/8 samples obtained from patients without capsular contracture (P = 0.0006) [ 18].
Forty-nine tissue samples were harvested at the time of implant removal from the anterior side of capsules surrounding breast implants from 41 female patients undergoing breast implant replacement or revision surgery.
Many clinical problems are associated with an excessive scar formation, for example, keloids and hypertrophic scars in the skin, tendon adhesions, transmission blockage following nerve injury, scleroderma, Crohn's disease, esophageal and urethral structures, capsules around breast implants, liver cirrhosis, atherosclerosis, and fibrotic non-union joint [17].
