Potential additive beneficial effects of treatment include vaginal atrophy, breast cancer prevention and heart disease.
Age-related atrophy of breast lobules (lobular involution) has been found to be inversely associated with risk of breast cancer [ 38], and it appears that PMD and lobular involution are independently associated with risk of breast cancer [ 39].
After NAC, normal breast tissue shows significant atrophy of the terminal ductal lobular units [ 107].
12 Lipodystrophy is characterised by fat accumulation (hypertrophy) in one or more anatomical sites (eg, abdomen, dorsocervical spine, breasts) or fat loss (atrophy) mainly on the face, buttocks and extremities or mixed lipodystrophy (combination of lipoatrophy and lipohypertrophy).
As a person ages, atrophy of the breast become progressive and fat tissue replaces the breast tissue.
To investigate the prevalence of urogenital symptoms and vaginal atrophy in postmenopausal breast cancer patients on adjuvant endocrine therapy.
The present data confirms and expands the putative associations between long-term androgen administration and abnormalities in ovarian architecture with macroscopic and microscopic characteristics of PCO, increased risk of endometrial atrophy and fibrotic breast tissue with marked glandular reduction.
Our recent findings (unpublished data) also find that the taxane-based regimen causes density atrophy in the normal breast.
The "Late Effects of Normal Tissue – Subjective, Objective, Management, and Analytic scales" (LENT-SOMA) are applied at week 13 asking for ulcerations, telangiectasias, palpatory changes, retraction, atrophy, edema in the breast, lymph edema, and fibrosis [ 52].
Breast hypoplasia or aplasia, nipple abnormalities, skin atrophy, and the absence of sweat glands and surrounding structures are other features [ 3– 5].
