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One of the methods researchers have for finding breakthroughs is to be provided with drugs to test.
But the principle established early on was that the best way to make breakthroughs is to hire the brightest scientists possible and let them determine what to do.
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One of his technological breakthroughs was to make artificial legs from recycled plastic yogurt bottles.
"A scientific breakthrough is to make functional cells that cure a diabetic mouse, but a major medical breakthrough is to be able to manufacture at large enough scale the functional cells to treat all diabetics.
The film industry's idea of a great feminist breakthrough is to applaud the tits of women over 40 as well as under it.
Prof Chris Mason, a stem cell scientist at University College London, said: "A scientific breakthrough is to make functional cells that cure a diabetic mouse, but a major medical breakthrough is to be able to manufacture at large enough scale the functional cells to treat all diabetics.
"There should [also] be active research on developing a methodology of feeding the plant which is environmentally benign, if the real potential of this genetic breakthrough is to be realized," he says.
Adidas' breakthrough was to let Yamamoto run wild.
His breakthrough was to convince Hearst that he could publish Esquire in Spanish.
"The conceptual breakthrough was to realise that innovation doesn't always come from spending more.
Dr. Fenn's breakthrough was to turn a solution containing the proteins into vapor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com