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The introduction of organic frameworks designed to coordinate metal ions or chelates to medical imaging has allowed for significant breakthroughs in the identification of many disease states.
Over the past few years, significant breakthroughs in the identification of ligands both from natural as and from synthetic sources have occurred, as reviewed by Burris [ 97].
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About a half-hour earlier, Mr. King had reported a "breakthrough in the identification of a suspect" and included details of a physical description.
Thus, analyses of cancer RNA and proteins provided a critical breakthrough in the identification of oncogenic gene fusions in common carcinoma.
A major breakthrough in the identification of molecules involved in temperature sensing was the discovery of temperature-activated transient receptor potential (TRP) ion channels that were directly gated by a change in temperature.
The finding by Grollman et al. of AA-derived DNA adducts in renal cortical and urothelial tumour tissue of patients with documented BEN, associated with the dominance of the A T → T A transversions in the p53 tumour suppressor gene mutational spectrum, was a breakthrough in the identification of AA as an aetiological agent of the upper tract malignancy observed in BEN [ 64].
Interesting breakthroughs were in the identification of p53 as inhibitor of metabolism, [ 58, 92- 94] its role in autophagy, [ 95, 96] it roles in induction of necrosis [ 97] and other diverse activities [ 98- 110].
A major breakthrough was the identification of a common epitope in oligomers formed by various amyloidogenic proteins (Ref. 7).
But it is frequently collaborative, and even when it is not, it is more often manipulative than violent.Modern Darwinism's big breakthrough was the identification of the central role of trust in human evolution.
Since the discovery of catalytic RNAs in the early 1980s, a recent breakthrough came from the identification of a wealth of micro RNAs, small interfering RNAs and regulatory RNAs, all involved in modulation of gene expression.
Here we present a Renilla luciferase-based technology breakthrough that allows the identification of regulated protein-protein interactions in rice in near-real time, which can also be expanded to a large-scale analysis.
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