Over the past years, technology breakthroughs in single-cell omics have enabled genome-wide profiling of genetic mutations22, copy number variation23,24, DNA methylation24,25, chromatin-accessibility26, and gene expression at the transcriptional level27.
Technical and analytical breakthroughs in the study of single cells have leveraged cellular heterogeneity to gain phenomenological and mechanistic insights of the phenotypic transitions that occur within isogenic cell populations over time.
Data gathered from breakthroughs in biochemistry, crystallography, and single molecule fluorescence have established a rich basis of information for the study of molecular mechanisms in the allosteric couplings of such transmembrane proteins.
"Because tennis in Canada hadn't really had singles breakthroughs in decades, he inspired the next generation.
Comparison of breakthrough curves collected for 2,4-D in single- and multi-component solutions shows that there is little, if any, difference in transport behavior over a wide range of pore-water velocities (70, 7, 0.66 and 0.06 cm h−1).
We strongly believe that the approach to design and manufacture MEMS devices based on requirements in single molecule measurements might provide breakthroughs and powerful tools in molecular biology.
During recent years, significant breakthroughs in developing high-throughput array-based single nucleotide polymorphism (SNP) genotyping assays for model organisms have been achieved which allow screening of thousands of loci in a highly parallel fashion [ 1- 3].
Smith, who came to prominence by singing the hook in Disclosure's breakthrough single Latch in 2013, hit a home run this year with this secular hymn to a love that's deeper and longer-lasting than a one-night stand.
At 8 p.m., Brooklyn Bowl, 61 Wythe Avenue, Williamsburg, Brooklyn, (718) 963-3369, brooklynbowl.com; $15. (Anderson Asher Rothh (Tuesday) This laconic rapper drawled out the benefits of cheap pizza and plentiful hooch in his breakthrough 2009 single, "I Love College".
The Beatles CD has 27 songs that were No. 1 in either Britain or the United States, from "Love Me Do" (their first in England) through "I Wanna Hold Your Hand" (their breakthrough single in the United States) to "The Long and Winding Road".
The breakthrough came in a single word, in a poem from his second book, "Door Into Dark".
