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To chronicle the trial of the drug known as PLX4032 is to ride a roller coaster of breakthroughs and setbacks at what many oncologists see as a watershed moment in understanding the genetic changes that cause cancer.
The recent introduction of the CFTR potentiator ivacaftor into the therapy of a subgroup of patients with specific CFTR mutations was a major milestone and enormous stimulus for seeking effective ion transport modulators for all patients with CF. In this review, we discuss recent breakthroughs and setbacks with CFTR modulators designed to rescue mutant CFTR including the common mutation F508del.
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He was right, as proved by the conflicting headlines about progress and setbacks, breakthroughs and disarray.
You will have successes and setbacks, too.
Too many injuries and setbacks to contemplate.
Sometimes life deals out injuries and setbacks.
The new development ends years of dashed dreams and setbacks.
The work continues round the clock, and setbacks do occur.
A series of embarrassments and setbacks for Chávez followed.
His personal self-belief remains unaffected by events and setbacks.
It primarily has to do with height and setbacks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com