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A major breakthrough was achieved with the discovery of the first well-tolerated orally available agents.
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Following the identification of SOD1 aggregates in a small subset of ALS patients, a breakthrough was achieved in 2006 with the identification of TDP-43 as a major component of ubiquitinated inclusions in FTLD and ALS cases [ 6, 150].
A major breakthrough was achieved a decade later with the almost concurrent discovery of three different linear-time algorithms by Kim et al. [ 19], Kärkkäinen and Sanders [ 20] and Ko and Aluru [ 21].
A major breakthrough was achieved when the first causative mutation was identified in a family with IIP.
Delayed breakthrough was observed for higher bed depth, while faster breakthrough was achieved for enhanced flow rate and inlet concentration.
The president's spokesman, Joe Lockhart, said that, as expected, "no breakthrough" was achieved.
A breakthrough was achieved in October, resulting in a nine-point draft agreement.
It was observed that quicker breakthrough was achieved for higher flow rates of As V) solution.
In 1974, one breakthrough was achieved by Lim using Edelstein's method of asymptotic centers [3].
A significant breakthrough was achieved when the study of membrane protein conformation became possible.
The real breakthrough in the practical application of NMR was achieved with the introduction of the legendary A-60 spectrometer in the year 1961.[ 8, 9] It reached a "fame" comparable to that of the Ford Model T among the early automobiles.
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