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When, during a tough period in her life four years ago, Atkin did approach a doctor for the first time, they advised her that she was already engaged with what therapists would call advanced, breakthrough stages.
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At a party before Rickman's breakthrough stage performance in Les Liaisons Dangereuses at the RSC, he recalled Rickman saying: "I'm nearly 40 and nobody here knows who I am".
So these might indicate this well has not totally stepped into complete breakthrough stage.
But Bikel's breakthrough stage role in London was in the 1949 production of "A Streetcar Named Desire," and he was nominated for an Oscar for playing Southern sheriff Max Muller in the film "The Defiant Ones," directed by Stanley Kramer.
Such a system should be construed as the upper bound of complexity for the breakthrough stage (Fig. 1).
Therefore, under this cosmology, an entity as complex as a coupled translation-replication system should be considered a viable breakthrough stage for the onset of biological evolution.
The pertinent question is whether or not this is the most likely breakthrough stage the appearance of which on earth would be explained by chance and anthropic selection.
Specifically, it becomes conceivable that the minimal requirement (the breakthrough stage) for the onset of biological evolution is a primitive coupled replication-translation system that emerged by chance.
The requirements for the emergence of a primitive, coupled replication-translation system, which is considered a candidate for the breakthrough stage in this paper, are much greater.
The evolutionary path from the breakthrough stage outlined above to the modern-type translation system was, largely, a story of takeover of the primordial ribozyme functions by evolving proteins.
The strong form of the present hypothesis, i.e., the notion that the breakthrough stage in the history of life was a primitive coupled replication-translation system (Fig. 2), is falsifiable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com