We worked during a time of great breakthroughs in reducing maternal deaths and both of us emerged with a genuine belief that change was always possible.
Switching to natalizumab or immunosuppressants in patients with breakthrough disease is effective in reducing clinical activity of relapsing MS. The magnitude of the effect and the risk-benefit ratio should be evaluated in randomized clinical trials and prospective cohort studies.
However, Walsh et al. (2002) demonstrated that VOR was superior to liposomal AMB in reducing documented breakthrough fungal infections (p = 0.02), severe infusion-related toxicity (p < 0.01), and renal toxicity (p < 0.001) in patients with febrile neutropenia [ 2].
This is an important breakthrough in helping to reduce the stigma and discrimination that people with mental illness face all over the world.
A major breakthrough in efforts to reduce the incidence of TRALI has been to exclude female donors of products with high plasma volume, resulting in a decrease of roughly two-thirds in incidence.
This leads to early a CO2 breakthrough, unstable pressure distribution, viscous fingering, channeling and bypass oil resulting in reduced oil recoveries.
The implementation of transition programmes in the Netherlands following the Breakthrough Series approach reduced bottlenecks in care delivery as perceived by professionals.
Further it was studied that the steepness of the breakthrough curve reduces with decreasing flow rates i.e., increase in breakthrough time.
Nonspecific changes in the output signal because of fluctuations in temperature, pH and electrical breakthrough were significantly reduced due to the differential mode of measurements.
Infectivity of breakthrough cases is reduced (e i = e s) in panels B and D, which show that even if the attack rate is small when the vaccine is delivered, the effectiveness of the vaccination campaign is substantially decreased.
