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The recent breakthrough in determining the crystal structure of rhodopsin has confirmed the general expectation that GPCRs are composed of seven helical transmembrane segments connected by intracellular and extracellular loop segments, as well as the expected topology of an extracellular N terminus and an intracellular C terminus.
Genes involved in rare mutations that completely inhibit normal ripening have been identified; such advancement is considered as a major breakthrough in determining the transcriptional control of tomato ripening [ 20].
In reality, the major breakthrough in determining the potential role of B cells in diseases occurred when two distinct cytokine-secreting subsets were identified through the culture of B cells with effector T cells associated with their cognate antigens [ 15].
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It has the optimum capabilities for the next breakthroughs in determining the origin of γ-ray bursts and their afterglows, as well as for using bursts to probe the early Universe.
Recent breakthroughs in determining the structure and antigenic content of the fusion (F) glycoprotein in its metastable untriggered prefusion form (pre-F) and the stable rearranged postfusion form (post-F) have yielded vaccine strategies that can induce potent neutralizing antibody responses and effectively boost pre-existing neutralizing activity.
In 2009 there was a major breakthrough in this endeavour with the discovery that single nucleotide polymorphisms (SNPs) linked to the cytokine IFNλ3 (also known as IL28B) are a dominant host factor at a population level in determining treatment outcome.
68Ge breakthrough was determined in each sample.
An audit heralded last year by L.A. city leaders as a breakthrough in efforts to determine what two controversial Department of Water and Power nonprofit trusts did with tens of millions of ratepayer dollars has ground to a halt, The Times has learned.
This group had a breakthrough paper in 2012, determining the Lis1-binding domain on the dynein motor domain, and using elegant single molecule studies to develop a clutch model for Lis1-mediated regulation of dynein motility.
The breakthrough curves were determined in open system for different initial chromium concentrations.
We sequenced plasma virus at two timepoints following this virus breakthrough in both animals to determine whether variation in Mamu-B*08 epitopes could account for their loss of control.
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