The award is in recognition of breakthrough research demonstrating the efficacy of an innovative combination therapy for treating mantle cell lymphoma.
We are not aware of any randomized controlled studies that have investigated the impact of IR opioid rescue medication use for breakthrough pain on the efficacy and tolerability of chronic opioid therapy in patients with chronic non-malignant pain.
We found no evidence that rescue medication with short-acting opioids for breakthrough pain affects analgesic efficacy of long-acting opioids or the incidence of common opioid-related side-effects among chronic non-malignant pain patients.
Despite these breakthrough infections, however, high vaccine efficacy against chronic HBV infection continued throughout childhood [ 12- 21].
The Cancer Society Symposium 'Immunotherapy of Cancer Present Status and Future Promise´ was held at a time when immunotherapy is experiencing a major breakthrough in terms of clinical efficacy and proving its value as an important treatment modality for cancer.
There have been a number of breakthroughs improving the specificity and efficacy of CRISPR/Cas-mediated genome editing.
Accelerate real-world evidence: Building on the recently passed 21st Century Cures Act, the report calls for incorporating and learning from the vast sums of patient data which may hold the keys to better care, improved drug safety and efficacy, and scientific breakthroughs.
Kern, K. A. Trial design and efficacy thresholds for granting breakthrough therapy designation in oncology.
While previous studies have provided a rationale for switching to another therapy in breakthrough disease, none has evaluated the efficacy of switching to second-line monotherapy versus controls in this context [3], [4], [5], [6].
Further studies are warranted to evaluate, in comparison with other short-acting opioids, its efficacy in the management of breakthrough cancer pain, its addictive potential and its economic impact in cancer patients.
