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Pertussis vaccination protects infants and children against death and admission to hospital, but breakthrough disease in vaccinated people can happen.
An important subgroup of patients experience breakthrough disease on glatiramer acetate or IFNβ within 2 years of treatment initiation.
One approach to managing patients with breakthrough disease is to switch them from one first-line therapy (e.g., glatiramer acetate) to another (e.g., an IFNβ formulation).
The effect of natalizumab monotherapy in patients with breakthrough disease is unknown.
Multiple sclerosis (MS) patients with breakthrough disease on immunomodulatory drugs are frequently offered to switch to natalizumab or immunosuppressants.
We also excluded reasons other than breakthrough disease for stopping first-line DMT such as poor compliance or side effects.
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A breakthrough on disease control, conversely, would help to unleash a virtuous circle of rising productivity, better education, lower fertility rates -- and then lead to further increases in health and prosperity.
He joined the Mount Sinai School of Medicine in Manhattan as an assistant professor, exploring genetic and other medical data in search of breakthroughs in disease modeling and treatment.
Animal testing, he said, has not led to medical breakthroughs "for diseases like AIDS, or other illnesses that are increasingly affecting humans: cancer, autism, Alzheimer's, and diabetes".
Regarding disease breakthrough, two overarching challenges are faced by neurologists: first, how to judge what level of disease breakthrough merits a change of treatment, particularly if the patient is accustomed to and comfortable with their existing therapy; and second, whether to escalate therapy.
"Breakthrough", "new hope", "disease could be prevented by immune system tweak".
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CEO of Professional Science Editing for Scientists @ prosciediting.com