The number of new agents discovered following this approach that are found in the advanced stages of the antibiotic pipeline is still very limited; however, the exploitation of bacterial genomics has been a major breakthrough for discovery and development of new antibiotics active against multiresistant pathogens.
In addition, a fascinating hypothesis raises from the inspection of the proposed SHP structure: the presence of a potential unexpected ligand binding site, supported by recently available experimental data that may represent a breakthrough in the design and development of synthetic modulators of SHP functions.
A major breakthrough was the improvement and development of high-throughput next-generation sequencing technologies.
For those of you who have been patiently awaiting a commercially viable alternative to our economic dependence on oil, natural gas and coal, the past year has seen some very encouraging technology and business breakthroughs in the growth and development of a modern bio-based economy.
This review presents the progress and breakthroughs in design, development and clinical application of selected cell-based tumor vaccines achieved due to the generation and development of gene transfer technologies.
Recent research on luminescent nanomaterials provides challenges to both fundamental and breakthrough development of technologies in various areas such as electronics, photonics, display, lasing, detection, optical amplification, and fluorescent sensing in biomedical engineering and environmental control [1].
The sale, which analysts estimate could bring as much as $4.5 billion, could lead to a breakthrough for development of Mozambique's considerable energy resources by potentially bringing in a large industry player to provide expertise and capital.
The breakthrough in development of biological agents for the treatment of RA was to target the immune system, which was ascribed to new insight into the major biological function of TNF-α in joint inflammation and destruction.
In this issue, Cell & Bioscience presents a series of reviews attempting to define the most challenging questions in DNA damage response and repair, and to provide an overview of the latest breakthroughs and developments in the field.
