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Centbucridine (4-N-butylamino-1,2,3,4-tetrahydroacridine hydrochloride) is a local anesthetic that did not show genotoxic effect when DNA breaks were evaluated in liver cells or by CA and SCE in bone marrow cells following a single acute exposure in mouse model [ 74].
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The size and shape of the 'zone of influence' resulting from the stress concentration effects around the fiber breaks are evaluated in both cases.
Animals were allowed to explore the altered environment for 2.5 min, after which, the conditioned stimulus (tone) is presented for 2.5 min. Activity (beam breaks) was evaluated in 30-second bins.
Micronuclei, a form of chromosomal damage that arises mainly from DNA double-strand breaks, were evaluated by the cytokinesis block technique (described in Autsavapromporn et al, 2011).
To confirm the lack of apoptosis in factor-treated cultures, the presence of DNA strand breaks was evaluated by in situ labeling (TUNEL) (Fig. 3b).
Methods: In 2010 2011, DNA strand breaks and nuclear abnormalities were evaluated in exfoliated buccal cells by the comet and micronucleus assays, respectively, and formaldehyde and NO2 were monitored by passive sampling.
The total set of pair-wise SNP-expression comparisons was broken into 99 equal subsets, which were evaluated in parallel across 99 individual compute node instances.
The amount of DNA-strand breaks was evaluated by the alkaline comet assay as described in Verschaeve et al. [ 49].
Preoperatively and postoperatively patients were evaluated in terms of corneal epithelial defects, Schirmer's test, and tear break-up time (TBUT).
Fundamental rheological properties were evaluated in controlled kinematic conditions and the results obtained were compared with traditional procedures such as the Fraass breaking point.
All conditions were evaluated in duplicate.
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