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Clinical experience showed that patients who had breaks of therapy longer than a week could not have treatment reinitiated at a dose of 190 mg m−2 without unacceptable toxicity.
Clinical experience also showed that patients who had breaks of therapy longer than a week could not have treatment reinitiated at a dose of 190 mg m−2 without unacceptable toxicity.
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I see a new trend here, there are a number of private events I go to that are mostly about technology but end up having small off the record sessions or conversations about relationships, divorce, breaking-up... benefits of therapy and even... talking about the pros and cons of drugs, which is unrelated.
The median time between the first statin dispensing to the index date was approximately 600 days for both cohorts, with 18% of the cancer cohort and 26% of the comparison group having at least one period of at least 90 days between dispensing records; median duration of breaks in therapy were 136 and 142 days in the cancer and comparison cohorts, respectively (table 1).
MTP consisted of a maximum of 12 additional outpatient sessions on five consecutive days from 9.00 am to 4.00 pm with a break of 1 h (30 h of therapy).
Possible undesired „side-effects" may include transient worsening of symptoms and transient risk of suicidality at the beginning of therapy (due to breaking out of avoidance behavior), but was rarely observed [ 28].
* incomplete = reduced amount of therapy or therapeutic break Complete initial luminal response of the primary CRC, with no malign tumor material at biopsy, was found in 10/20 (50%) of the cases.
Local toxicity: the forms of acute toxicity observed were mucosal and skin reactions corresponding to WHO grades 1 or 2 apart from four patients; one each in Protocols A and B and 2 in Protocol C. Two of these patients (belonging to Protocol A and B) required a break of 1 1.5 weeks before resumption of therapy and one patient required an enteral tube after termination of the therapy.
For the purpose of this analysis, deintensification of therapy for adverse events, or planned treatment breaks were considered as same line of therapy.
A sequence of therapy starts with full therapy and may include planned/unplanned partial treatment breaks or treatment-free interval (i.e., complete stop of therapy), and ends with one of the following events (whichever occurs first): disease progression occurring on full therapy or during a partial or complete stop of therapy without any possibility of resuming full therapy.
Lots of therapy.
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