Identical CNV breakpoints were found for multiple, unrelated subjects at the sequence level.
No differences in the distribution of breakpoints were found between the different studied groups, viral subtypes or treatment response.
In the other two families, no homologous sequence flanking the breakpoints was found, but the distal breakpoints were embedded in novel low-copy repeats, suggesting the potential involvement of genome architecture in stimulating these rearrangements.
Further telomeric, 11q breakpoints are found in many cancers.
The genomic coordinates of each breakpoint were found and the genomic gap size calculated.
A rare 142 508 bp loss (17 269 780–17 412 288), involving the typical 22q11.2 deletion's proximal breakpoint, was found with one algorithm in a proband and unaffected father on whose chromosome arose the 22q11.2 deletion with an atypical proximal breakpoint about 360 kb distal at 17 774 335 (Atypical 1, Table 1).
When both rearrangement breakpoints matched a copy number breakpoint, the sum of the distances between the rearrangement and the copy number breakpoints was below 400kb, and when for only one rearrangement breakpoint a corresponding copy number breakpoint was found, the distance between both breakpoints was below 20kb.
In contrast, a breakpoint was found when a similar procedure was applied to the malaria incidence time series, on December 2002 955% confidence limits September 2001 February 2004), as shown by the minimization of BIC for one breakpoint in Figure 3B.
A single breakpoint was found at position 567 by GARD.
A total of 41 breakpoint intervals were found to be shared by these species, whereas 323 breakpoint regions were unique to the species considered.
