Sentence examples for breakpoints were enriched for from inspiring English sources

In addition, we explored if CNV breakpoints were enriched for GC-rich regions which were likely to show high rate of homologous recombination [ 54].

The present study indicates that, at least in the primate lineage, the evolutionary breakpoints are enriched for SDs whilst overlapping to a similar extent with sites of known copy number variants.

Although SM breakpoints are enriched near genes for the ETS+/CHD1wt subtype, protein binding enrichment around SM breakpoints is even higher far away from genes than near genes.

It was reported that ~20% of breakpoint regions were reused during mammalian evolution and the sites were enriched for centromeres [ 24].

We find in all prostate datasets that genomic rearrangement breakpoints are enriched in late-replicating DNA (WA < 20) and deplete in early-replicating DNA (WA > 75) in PrEC (Fig. 6a).

Since evolutionary breakpoints are enriched with SDs in many species [ 8- 12], we assessed the sequence features of SDs located at the breakpoints of inversions separating humans and chimpanzees.

Moreover, 23 MMU breakpoints are enriched only in ERV-L (MT2A, MT2B B or RMER10) or ERV-K RMER17C.

Both reactors were enriched for "A.

Both breakpoints were found to be enriched for low copy repeats, which, according to the Segmental Duplication Database (http://humanparalogy.gs.washington.edu/), share a 49.9 kb segment with 95% sequence similarity (no.9417), and the proximal breakpoint coincided with published DNA copy number variants.

The analyses suggest that evolutionary breakpoints are clustering in 'hotspots', that these regions are enriched for centromeres and that the more commonly occurring human cancer-associated breakpoints tend to co-localize with evolutionary breakpoints.

In addition, it has been reported that the breakpoints for the chromosomal inversion 2La appear to be enriched for LTR transposons [ 41].