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The bacteriostatic and bactericidal breakpoints were determined as the highest MIC values at which the bacteriostatic and bactericidal probabilities in PF were ≥80%, which values varied with drug and dosing regimen.
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The real breakpoint is determined as the last nucleotide before the inserted sequence.
Domains were defined as individual introns or exons, recombination breakpoints were determined both by visual inspection of the alignment and use of RDP.
Recombination breakpoints were determined by checking the positions where genotypes change.
Recombination breakpoints were determined by the junction of two different genotypes.
Consensus daughter sequences and breakpoints were determined whenever possible.
Breakpoints were determined molecularly by genomic PCR and sequencing.
To map MUL1 imprecise excision lines, breakpoints were determined by genomic PCR followed by DNA sequencing.
Breakpoints were determined after the Clinical and Laboratory Standards Institute (CLSI) guidelines [ 14].
Based on the Global Genomic Index (GGI), which corresponds to the fraction of the genome involved in CNA and the number of breakpoints (nbBP), which were determined as chromosomal sites where copy number shifts occurred, we defined two classes of tumors showing strong differences in outcome and hazard risk.
The breakpoints in these lines were determined as precisely as possible and further supported by refinement of the breakpoints in susceptible lines 6 and 9, which have the smallest portion of chromosome 17 from the BR strain that causes an increase in liver tumor susceptibility.
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