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# The fragment numbers were consistent with those of Fig. 1D and 2 B. * The FORS-D values of breakpoints were calculated as described in the Methods.
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In order to further confirm the relationship between recombination and high negative FORS-D values, FORS-D values of corresponding breakpoints of parent sequences were calculated as described in the Methods.
EC50 values were calculated as published [60].
IC50 values were calculated as described.
All values were calculated as mean±SD.
Data were calculated as means ± SD.
Proliferation indexes were calculated as before.
Tumor volumes were calculated as described above.
Data were calculated as Mean ± SEM.
Fold changes were calculated as –ΔΔCt±SD.
For example, the fraction of coverage in the 100 kb-200 kb range from breakpoints in the Breast-Stephens callset, was calculated as where H TAF 1, GM 12878, HAIB, experiment denotes a set of all genomic positions under at least one ChIP-seq peak for TAF1 in the GM12878 cell line in given experiment performed by the HAIB lab.
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