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Current CLSI breakpoints were applied for linezolid [ 14].
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Differentiation is also important with regard to resistance testing, since different antibiotic susceptibility breakpoints are applied for S. pneumoniae with regard to other viridans species [ 3].
For tigecycline US Food and Drug Administration FDAA) breakpoints were applied.
Imipenem and meropenem zone diameter breakpoints were applied to doripenem since the CLSI official zone diameter breakpoints for doripenem were unavailable.
These two antimicrobials were the only ones where human breakpoints were applied and emphasises potential species differences in pharmacokinetic and pharmacodynamic data for individual antimicrobials.
The results were interpreted in accordance with CLSI breakpoints, except for azithromycin, for which the European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints were applied [ 30].
Therefore, CSF isolates were excluded from the analysis when nonmeningitis parenteral breakpoints were applied.
The new species-specific CLSI candida MIC breakpoints were applied to these date.
Therefore, non-species related breakpoints of EUCAST were applied for fluoroquinolons and tigecycline.
According to the current CLSI guidelines [ 20], different susceptibility breakpoints have to be applied for penicillin G with regard to meningitis and non-meningitis cases.
We have developed a general strategy that can be applied for pinpointing the genomic breakpoints in unpurified primary cancers.
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