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Worm breakpoints in the human host are investigated in this approach as follows.
Ever since Nadeau and Taylor [2] published their groundbreaking paper on the distribution of synteny breakpoints in the human and mouse genome, it was commonly believed that breakpoints are essentially distributed at random.
We have shown an association between the density of interspersed repeats and the evolutionary breakpoints in the human and mouse genomes.
Korbel et al. [ 146] and Kidd et al. [ 154] systematically analyzed structural (rearrangement) variation breakpoints in the human genome, and have found that almost all breakpoints analyzed have signatures of one of the four mechanisms above.
After assessment of its performance, the predictor was trained on the whole data set (using opossum as an approximation to the ancestral context) and applied to the prediction of breakpoints in the human context.
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The deletion breakpoint in the human, chimpanzee and orangutan Duxbl locus was mapped using LAGAN in mVISTA http://genome.lbl.gov/vista/mvista/submit.shtml with species specific repeat masking and default parameters[ 42].
Here, we provide a highly refined description of the chromosomal reorganizations and evolutionary breakpoint regions in the human and rhesus macaque genomes based on orthologous genes and genome sequence alignments.
We first constructed a highly refined map of the structural rearrangements and evolutionary breakpoint regions in the human and rhesus macaque genomes based on orthologous genes and whole-genome sequence alignments.
Mouse-human breakpoint absent in the human-rat comparison suggests the rearrangement is specific to the mouse lineage, i.e. mouse-specific breakpoint.
We regard that both these density dependences are likely to independently and simultaneously act to affect the transmission of filariasis, via the introduction of vector biting transmission thresholds and breakpoint worm levels in the human population [10].
In our case, since we focus on breakpoints on the human lineage, the ancestral state can be approximated using the opossum local context.
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breakpoints in the male
breakpoints in the peri centromeric
breakpoints in the minor
breakpoints in the entire
breakpoints in the same
breakpoints in the progressive
breakpoints in the genus
breakpoints in the low-recombinant
breakpoints in the O-antigen
breakpoints in the current
breakpoints in the individual
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