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Differentiation is also important with regard to resistance testing, since different antibiotic susceptibility breakpoints are applied for S. pneumoniae with regard to other viridans species [ 3].
Therefore, some strains included in our study would be classified as imipenem and/or meropenem resistant if the most recent CLSI breakpoints are applied.
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For tigecycline US Food and Drug Administration FDAA) breakpoints were applied.
Current CLSI breakpoints were applied for linezolid [ 14].
Therefore, CSF isolates were excluded from the analysis when nonmeningitis parenteral breakpoints were applied.
The new species-specific CLSI candida MIC breakpoints were applied to these date.
The results were interpreted in accordance with CLSI breakpoints, except for azithromycin, for which the European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints were applied [ 30].
Imipenem and meropenem zone diameter breakpoints were applied to doripenem since the CLSI official zone diameter breakpoints for doripenem were unavailable.
These two antimicrobials were the only ones where human breakpoints were applied and emphasises potential species differences in pharmacokinetic and pharmacodynamic data for individual antimicrobials.
Our first-phase screening produced preliminary evidence of recombination in 426 (29.1%) of these 1,462 gene sets, and Bayesian inference of recombination breakpoints was applied to those 426.
Interpretive criteria for amphotericin B and posaconazole have not been established; instead, isolates inhibited by amphotericin B at concentrations ≤1 mg/L were considered susceptible and voriconazole breakpoints were applied to the posaconazole MIC values [ 18].
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