In such a case, there is the possibility that the energy required to break interactions with the solvent be higher than the energy released during its adsorption on the surface.
Podocyte effacement and detachment from the GBM could then follow these broken interactions between the cytoskeleton and the slit diaphragm.
Myocardial and endocardial signals then induce activation of endocardial cells, allowing these cells to break interaction with the neighboring endocardium and invade the cardiac jelly.
The simplification process works by starting with interactions and breaking those interactions into smaller interactions and main effects.
For both numerical models, the breaking wave interactions with the monopile were in good agreement with the experimental measurements.
Here by engineering intermolecular interaction through hydrogen bonding in polymer chains, a significant enhancement in thermal conductivity was achieved and corresponding decrement was observed by breaking those interactions.
Molecular dynamics simulations show that the phosphomimic mutation Y265E increases actin binding by breaking several interactions that tether the two calponin homology domains into a closed ABD conformation.
As seen from their melting temperatures, they require much less energy for disordering the crystal structure and breaking intermolecular interactions to achieve molecular motion above the melt point.
Some of these interactions aid in the assembly of the replisome (Zhang et al., 2011) and perhaps in proper positioning of the helicase with the DNAP in the replisome, but the consequences of breaking physical interactions on synergistic melting need to be investigated.
In addition to breaking these interactions in the signaling network, because the D665N mutation renders PKD1 a less specific kinase, we anticipate that the mutation will generate many new connections through phosphorylation of non-native substrates, some of which may contribute to the malignant phenotype.
Even though BbpThr582 and Leu584 could interact with the peptide by two pairs of main chain-main chain hydrogen bonds (Fig. 3C), the replacement to alanine might serve a similar role instead of breaking the interaction with the peptide according to the results here.
