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A final link of evidence indicating that increased autophagosome formation reflects increased autophagic activity is the demonstration by metabolic labeling that the rate of long-lived proteins breakdown was increased by CysC treatment under nutrition deprivation conditions.
For instance, Tiao et al. [ 6] found that in septic rats, skeletal muscle protein breakdown was increased due to enhanced activity of the proteolytic ubiquitin-proteasome pathway.
Furthermore, in a recent study in critically ill septic patients receiving PN, muscle protein synthesis was normal, but protein breakdown was increased up to 260% compared to healthy controls [ 26].
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A case-control study in Northern Ireland showed that the odds of a bTB breakdown are increased by more than two-fold if a herd has a contiguous neighbour which has experienced a confirmed bTB within the last three years [12], with a similar pattern once again observed in the Republic of Ireland [7].
Collectively, metabolic data indicated increased FA synthesis and decreased FA oxidation in the VEGF-B overexpressing hearts, whereas intermediates of glycogen and glucose breakdown were increased.
The number of breakdowns are increasing, even as older cars are being replaced by newer models.
The number of herds in GB is declining, whilst the number of breakdowns is increasing.
The property of breakdown showed contrasting responses to ozone in the two cultivars: the breakdown value was increased significantly in ozone-exposed "Koshihikari" but decreased in "Kasalath" (P < 0.05).
As the peak electric field at the drain edge was decreased, the breakdown voltage was increased by 66% compared with the AlGaN/GaN HEMT with the gate field plate only.
The SiN/SiC double-layer coating substantially improved the corrosion resistance of the metals: For SS301, the corrosion current, icorr, was reduced by more than three orders of magnitude, and the breakdown voltage was increased from 0.34 to 1.37 V.
Glycogen phosphorylase (PYGL), which catalyses the breakdown of glycogen, was increased under cold exposure (Fig. 6).
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