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This induced synovitis model using filipin demonstrated that cartilage degradation could occur in the absence of instability or traumatic disruption of the tissues and loss of glycosaminoglycan (GAG) staining was associated with early morphologic breakdown of the surface of the cartilage and loss of GAG staining throughout the ECM.
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Apparently, it is important to note that the certain additional conditions are necessary to facilitate the initial development of the breakdown on the surface of the nanobatteries.
An alternative additional condition to facilitate the initiation of the breakdown on the surface of the nanobatteries can be their high temperature.
The synthesis of aerosol nanobatteries; The pre-ionization and ignition of the initial breakdown on the surface of the nanobatteries.
Thus, apparently, there are two major functions of the electric discharge prior to the formation of ball lightning: (a) The synthesis of aerosol nanobatteries; (b) The pre-ionization and ignition of the initial breakdown on the surface of the nanobatteries. .
Bacterial infections of the cornea usually occur after injury to, or breakdown of, the corneal surface, as few bacteria have the power to penetrate the intact surface layers of the cornea.
Chronic repetitive loading of the articular cartilage during sports activity can lead to progressive articular cartilage degradation with accumulation of catabolic enzymes and cytokines, fragmentation of collagen and aggrecan, and resultant fissuring and progressive breakdown of the articular surface.
Thus, any breakdown of the corneal surface or penetrating injury to the cornea results in the release of IL-1 and subsequent proinflammatory signalling and upregulation of IL-6, IL-8, and more IL-1 in underlying keratocytes [ 43, 44].
11 Repetitive loading of the injured articular cartilage during sports activity leads to cellular degeneration, accumulation of catabolic enzymes and cytokines, disruption of collagen ultrastructure and progressive macroscopic breakdown of the articular surface.
Before the measurements of the breakdown voltage, the surfaces of the electrodes are conditioned by some pulsed discharges which results in acceptable reproducibility of breakdown voltage values (approximately 10-V difference at the minimum of Paschen's curves for each operations).
Such adsorption is expected to be sensitive to polymorphism and, for particles below 10 nm or so in size, new phenomena, reflecting the breakdown of the assumption of constant surface energies, may come into play.[19].[19]
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