Sentence examples for breakdown of matrix from inspiring English sources

MMPs are inhibited by mediators known as tissue inhibitors of MMPs (TIMPs) that highly regulate the breakdown of matrix.

Disc degeneration usually is associated with increased breakdown of matrix, decreased synthesis of aggrecan and collagen, cell loss through apoptosis, and cluster formation by surviving cells [ 4- 7].

The histone deacetylase inhibitors trichostatin A and butyrate were shown to drastically reduce expression of these enzymes relatively selectively, with concomitant inhibition of breakdown of matrix components.

Several steps are involved in the invasion and metastasis of malignant cells including the attachment of cells to the ECM, the breakdown of matrix components, cell detachment, and migration of cells through the degraded matrix.

These three proteases together are capable of degrading fibronectin and collagen IV, and shed Fas and kit ligand from epithelial cells in vitro[ 59] and thus may regulate the breakdown of matrix and differentiation of granulosa cells prior to ovulation.

The inhibitors of matrix metalloproteases, TIMP 1 and 2 are also critical players in the breakdown of matrix close to the time of ovulation [ 60, 61] and can promote progesterone synthesis.

Versican (VCAN) is an extracellular matrix proteoglycan already known to play a role in metastasis, while MMP11 is one of several matrix metalloproteinases involved in the breakdown of extracellular matrix.

Matrix metalloproteases are proteins involved in the breakdown of extracellular matrix.

Proteins of the matrix metalloproteinase family are involved in the breakdown of extracellular matrix in normal physiological processes and tissue remodelling, as well as in disease processes, such as tumour metastasis.

Matrix metalloproteases are key regulatory molecules in the breakdown of extracellular matrix and in inflammatory processes.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in liver repair reactions [ 30].