Finally, our model predicts that heterosis for most complex traits would arise primarily from complementarity between dominant or partially dominant regulatory genes and additive downstream ones, and inbreeding depression is due primarily to the breakdown of functioning FGUs by recombination.
Research in design rationale systems, product families, systems engineering, and ontology engineering has sought to capture knowledge from earlier product design decisions, from the breakdown of product functions and associated physical features, and from customer requirements and feedback reports.
In short, although much remains to be learned about the regulation of bladder function, it is now established that the interactions between innervation, ICs and urothelial cells are complex and that regulation of bladder function depends upon integration of their individual activities, hence there is significant potential for breakdown of bladder function during ageing.
Moreover, among the several allelic variants of SLF from A. hispanicum and P. hybrida with which PhSSK1 was found to interact, only the function of AhSLF-S 2 in SI has been demonstrated through its causing the breakdown of SI function in transgenic pollen of a self-incompatible P. hybrida line (Qiao et al. 2004 b ).
Perhaps more threatening to the whole-brain approach is the growing empirical evidence that total brain failure is not sufficient for human death —assuming the latter is construed, as whole-brain advocates generally construe it, as the breakdown of organismic functioning mediated by the brain.
Like other forms of the virus, hepatitis A is highly infectious and causes a breakdown of liver function which causes Hep A's tell-tale yellow eyes and skin.
The respiratory chain malfunction can also lead to increased ROS production, constituting a reinforcing vicious cycle and possibly resulting in catastrophic breakdown of mitochondrial function [37].
Excess generation of reactive oxygen species can attack membrane lipids and then lead to a breakdown of membrane function.
There are studies showing that breakdown of BBB function may be a consequence of an inflammatory response and that inflammation is a cause for P-gp upregulation (33).
VEGF inhibition can lead to breakdown of glomerular function, and this may be due to the effects of VEGF on endothelial fenestrations combined with its survival effects on podocytes themselves.
Either catastrophic breakdown of mitochondrial function or simply a contribution by p53 to chronic mitochondrial dysfunction might be a factor underlying the aging process (Wallace, 2005), which could be offset by p53 reduction.
