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Cells that express a translocating γ subunit demonstrate attenuated PIP2 breakdown in response to M3 receptor stimulation compared to cells that express a non translocating γ subunit.
CK is considered the primary marker for muscle breakdown, in response to exercise, a portion of the population has exaggerated increases in CK [ 31, 32].
In vivo studies have indicated that starvation-stimulated macroautophagy provides the liver with a lipid challenge in the form of increased serum FFAs and that the autophagic pathway selectively targets lipids for breakdown in response to this physiological stimulus [ 11].
In humans, changes in muscle protein synthesis (MPS) and breakdown in response to food intake and/or exercise are normally assessed in vastus lateralis muscle (Rennie et al. 1982).
Furthermore, activation of c-Jun N-terminal kinase (JNK) promotes lysosomal breakdown in response to TNF-α, TRAIL, and UVB radiation, possibly via activation of the BH3-only-domain protein Bim [ 50, 95, 96].
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A similar breakdown was found in response to questions about the economy.
A transcription factor called LXR regulates the production and breakdown of cholesterol in response to changing levels of cholesterol in the body.
Thus, we conclude that the breakdown of the vasculature in response to the antiangiogenic treatment strongly impairs the delivery of the probe to the tumor tissue, consequently resulting in a low probe accumulation despite the enhanced apoptosis.
Breakdown of the BBB in response to intrastriatal cytokine/chemokine injections has already been described before [ 17, 18].
In a research setting, whole-body protein synthesis and breakdown can also be measured in response to protein feeding or PN.
Edema formation in stroke causes an increase in cell volume, depolarization, breakdown of ionic gradients, cellular ATP depletion, and finally vasogenic edema in response to BBB breakdown [8].
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