Sentence examples for breakdown and activation of from inspiring English sources

Inactivity is a potent stimulus to muscle protein breakdown and activation of the ubiquitin proteasome pathway of proteolysis [48].

Tram and Sullivan observed that a delay in nuclear envelope breakdown and activation of cyclin-dependent kinase 1 (cdk1) in the male pronuclei occurred relative to that in the female pronuclei in Nasonia [11].

Infections and endotoxemia reduce respiratory muscle strength, probably acting through several mechanisms - including increased oxidative stress, caspase activation leading to protein breakdown, and activation of the proteasome and calpain proteolytic systems resulting in protein loss.

Some remarkable features observed in CI embryos include delayed paternal nuclear envelope breakdown and activation of Cdk1 [ 34], a failure of the maternal histones H3.3 to deposit in the paternal genome, and slowed replication of sperm DNA [ 35].

At the cerebrovascular level this promotes oxidative damage and BBB breakdown via tight junction (TJ) modification and activation of proinflammatory pathways [ 25, 26].

Deep WMH lesions are thought to result from chronic hypoperfusion and hypoxia in terminal vascular beds fed by long, penetrating arterioles [ 31] and/or from breakdown of the blood-brain barrier and activation of matrix metalloproteinases [ 32, 33].

This, together with the expression of pro-inflammatory mediators, used for (and by) the recruitment and activation of leukocytes results in inflammation, tissue breakdown and ultimately a characteristic menstrual bleeding [4, 6, 12], after which the pain tends to subside.

Therefore, we especially investigated the mitochondrial-dependent events during apoptosis, such as breakdown of mitochondrial membrane, expression of Bax and Bcl-2 and activation of caspase 9.

Aberrant expression and activation of EGFR in malignant cells might lead to breakdown of immunotolerance.

MMPs could play a multifaceted role in such a phenomenon, modifying the tumor microenvironment through direct breakdown of matrix proteins and basement membrane barriers, promotion of angiogenesis, and/or the release and activation of growth factors [ 18].

The breakdown of large lipid droplets in obese women could cause an increase in saturated fatty acid (FAS) production and activation of inflammatory signaling pathways such as NF κB activation.