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Even fragile sites that coincide with tumor suppressor genes (44), the breakage of which might affect carcinogenesis directly, represent only a small fraction of breakpoints in sporadic carcinomas (28).
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The breakage of lipids, which accompanies the formation of reactive oxygen species, can also lead to modifications of membrane permeability and fluidity and, as such, can dramatically alter cell function.
The results also show that geogrid minimises the amount of particle breakage, the effectiveness of which is governed by its placement position, with lowest breakage occurring when the geogrid is placed at a location 130 mm above the subballast.
GARD analyses generated eight predicted breakage points, two of which showed statistically significant topological incongruence at p = 0.05 (Table 3).
On the lingual side, two long furrows are visible, and on the buccal side breakage exposes three long infundibula, of which the most mesial one is the longest and the most distal one the shortest.
As a counterpart to this approach, the assay has been used to study the suppression of this breakage with chemopreventive agents, some of which occur naturally in the diet.
In contrast to the breakage of hard agglomerates which break in large fragments, as commonly investigated, loose agglomerates break in finer fragments.
The increase in the Al O/Al N intensity ratio after RTA can be attributed to the breakage of Al N bonds which are metastable with respect to O.
However, when the agglomeration efficiency exceeds 80% at the later stage of the process, some discrepancy is observed due to the breakage of large aggregates which is not taken into consideration in the modeling.
The RNA isolation procedure we used involves a short proteinase K digestion, followed by incubation at 70°C under conditions that promote breakage of methylene crosslinks which result from formalin fixation.
The data are consistent with the hypothesis of transversal breakage of the fibers, which increases the percentage of SAF.
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