Sentence examples for break up linkage from inspiring English sources

Depending on the speed at which this occurs, there may not be sufficient time for recombination to break up linkage groups and population samples may be comprised of representatives from a small number of clones.

The longer linkage in fragment 5 (env) might have several reasons that extend beyond our simple argument: (i) homologous recombination might be suppressed in the most variable regions, (ii) the accuracy of SNP frequency estimates is lower in F5 due to poorer amplification, and (iii) the rapid evolution of env due frequent substitutions and sweeps gives less time to break up linkage.

We further illustrate the effect of extra recombination on allele frequency differences in Figure 2. Taken together, these results show that the ability to detect and localize QTL depends crucially on recombination, both to decrease interference between QTL and to break up linkage between QTL and nearby neutral variants.

The particular importance of including ancestral groups of non-European origin in these analyses is noted, in order to use their differences in linkage disequilibrium patterns to break up linkage disequilibrium blocks, and to demonstrate generalizability of variants associated with COPD to the population at large.

One explanation is the high level of linkage disequilibrium (LD) between markers and QTL and an insufficient number of generations to break up linkages, although predictions accuracies generally declined as expected.

Identifying inversion polymorphisms and selecting for homokayrotypic lines prior to inbreeding will also aid recombination in breaking up linkage blocks.

We found that recombination's positive effect of breaking up linkage between QTL and neutral sites outweighed the negative effect on haplotype frequency estimation.

In the context of the RQH, the benefit of genetic shuffling is associated with breaking up linkage disequilibria in the host population that are generated by selection pressures imposed by the coevolving parasite population.

A combination of binning and more stringent program settings reduced the degree of map expansion to a negligible level (2.8 ± 2.3%), but had the side effect of breaking up linkage groups (Table 2).

Underlying this approach is the rationale that recombination breaks up linkage with increasing genetic distance from the adaptive site: The farther away it is from the sweeping locus, the higher the probability that presweep variation has become unlinked from the adaptive allele and thus remains polymorphic after the sweep.

However, in clonal organisms such as bacteria, selection will affect diversity across the entire genome unless recombination breaks up linkages between genomic regions [ 24].