Sentence examples for break the tolerance from inspiring English sources

In conclusion, MHC-mismatched MSCs can break the tolerance to autoantigens and lead to the development of pathogenic autoantibodies.

As pointed out by a reviewer, better responses might have been achieved by adding in ubiquitous T cell epitopes or possibly even slightly varying the HBsAg sequence (e.g., by 5 7% mismatches) to help break the tolerance.

These observations demonstrate that IFNα has the capacity to both break the tolerance and enhance a smoldering autoimmune process.

To break the tolerance against TCL, carrier protein diphtheria toxin (DT) was conjugated to TCL, serving as vector for delivering B-cell and T-cell epitopes [22].

So, even a small amount of DI presented to the immune system can break the tolerance and easily induce specific antibodies.

Allogeneic MHC molecules are relevant to break the tolerance to HER-2/neu self antigen by stimulating multiple T cell clones and causing a broad production of immunostimulatory cytokines [ 17, 22].

Both vaccines broke the tolerance toward huHER2 and rapidly elicited anti-huHER2 humoral responses, with some differences in potency and kinetics between vaccines, which are in agreement with preliminary experiments.

Therefore, in HCV chronic infection, targeting NKG2A would break the immune tolerance of both NK and HCV-specific T cell response.

How can one break the immune tolerance induced by HBV?

The consistent picture regarding efficacy that emerges from quantitative virological and immunological data is that pSG2.HBS and MVA.HBV are unable to break the profound tolerance of the immune system to HBsAg in HBV chronic carriers.

Consequently, a successful antitumor immune response against such self antigens requires to break the immune tolerance.