Third, we break the domain-domain relationship by permuting connections in the underlying domain-domain interaction network, while keeping node degrees and recalculating the diffusion kernel.
Second, we break the domain-disease relationship by two methods: (1) permuting domain-disease associations and (2) replacing domains in known disease-domain associations with randomly selected domains.
The force-time curve (Figure 1G), shows that the average force is ∼90 pN indicating that at a target velocity of 1.0 Å/ps, the ∼90 pN generated at the beginning of a pulse, is insufficient to break the I27 domain out of the folded minimum.
The traditional technique to simulate physical systems modeled by partial differential equations consists of breaking the simulation domain into a spatial grid and then advancing the state of the system synchronously at regular discrete time intervals.
First, a physical field is required to break the symmetry of the spatial domain into different regions in which distinct sets of transcription factors are expressed and exert their function.
These amorphous domains break the Gly-X alternate and terminate the crystalline regions.
The TE domain is proposed to break the thioester bond connecting the hapalosin chain to the ACP domain, enabling the oxygen of C8 to attack C18, forming the cyclised final structure.
To calculate the transmission characteristics of the entire network, frequency-domain methods break the entire network into several cascaded sub-networks and calculate the transmission matrix [13 15] or scattering matrix [16 18] for each sub-network.
Each of the local models is obtained by giving full attention to a reduced portion of the space of the possible behaviors, yielding a more accurate description even when simple approximations are used: therefore this approach refers to the concept of breaking up the domain into several small neighboring regions and analysing these separately.
Interestedly, all our anti-RTB mAbs did not bind to RTB when the four intrachain disulfide bridges in RTB were broken and the domain structures were disturbed, indicating that all four mAbs most likely bind to conformational epitopes on RTB.
