Sentence examples for break hr from inspiring English sources

DEGs, differentially expressed genes; DSB, double strand break; HR, homologous recombination; KO, knock out; MMR, mismatch repair.

DSB: double strand break; HR: homologous recombination; HU: hydroxyurea; MRN: Mre11/Rad50/NBS1.

DSB – double strand break HR – homologous recombination NHEJ – nonhomologous end-joining CDS – coding sequence AP conceived the study and performed the data analysis.

In presence of a double-strand break, HR allows the exchange of the same genetic sequence from the healthy homologous sister chromatid to the damaged one [ 5] and therefore generally results in accurate repair of the break [ 6].

CGH: comparative genomic hybridization; DSB: double-stranded break; HR: homologous recombination; IHC: immunohistochemistry; LumA: Luminal-A; LumB: Luminal-B; NHEJ: nonhomologous end joining; SSA: single-strand annealing; TMA: tissue microarrays; TNP: triple-negative phenotype.

BE, base editor; C, cytidine; DSB, double-strand breaks; HR, homologous recombination; HF2-BE2, high-fidelity versiof of base editor 2; KSOM, potassium simplex optimized medium; NHEJ, non-homologous end joining; SNVs, single nucleotide variations; T, thymidine; T7EI, T7 endonuclease I; U, uridine; UGI, uracil DNA glycosylase inhibitor; WGS, Whole genome sequencing; WT, wild-type.

(DSBs): Double strand breaks; (HR): homologous recombination; (NHEJ): nonhomologous end-joining; (PCR): polymerase chain reaction; (RFLP): restriction fragment length polymorphism; (ORs): odds ratio; (CIs): confidence intervals.

RAD51 (Rec A homolog of E. coli) is a polymorphic gene and one of the central proteins in homologous recombination-DNA-double-stand breaks (HR-DNA-DSB) repair pathway, which is vital in maintaining genetic stability within a cell (Hamdy et al., 2011).

In the four major DNA repair pathways (double-strand DNA (dsDNA) break repair (HR and NHEJ), NER, BER, and mismatch repair), key proteins, including some with dual functions, participate in DNA damage sensing/repair and apoptosis (Table 1) [ 16].

What is typically observed in break-induced HR is that donor incorporation decreases with increasing distance from the site of the break.

Most importantly, BRCA1 plays a significant role in the repair of DNA DSBs (double stranded breaks) through HR (homologous recombination) [ 153].