Sentence examples for break checkpoint from inspiring English sources

It will be interesting to determine whether the DNA double strand break checkpoint is activated in spn-E ovaries and why I Factor levels are the most impacted by the spn-E mutation.

Interestingly, mutations in all known piRNA pathway components lead to oocyte and embryonic patterning defects and, ultimately, to sterility, believed to be an indirect consequence of transposon-induced genomic instability and activation of a DNA double-strand break checkpoint (Klattenhoff et al., 2007; Theurkauf et al., 2006).

Omcg1-deficiency in mouse embryonic fibroblasts induces a massive accumulation of double-strand breaks, checkpoint activation and replication forks collapse, as the consequence of R-loops formation (Houlard et al., 2011).

Clarifying the mechanism of downregulation of p53 in iTSCM cells will provide a new strategy for breaking immune checkpoint mechanisms.

The resulting situation became disorderly, with some Liverpool fans attempting to break through checkpoints, set up by the Greek police.

In addition to DNA repair, Ira el al. also found in yeast that Cdk1 is required for double strand break-induced checkpoint activation [ 40].

PALB2, partner and localiser of BRCA2, is a BRCA1- and BRCA2-interacting protein critical for the homologous recombination-based repair of DNA double-strand breaks and checkpoint control functions [ 14- 16].

This is important for two reasons: DNA breaks activate checkpoints that cause arrest of cell division, and DNA breaks engage repair machinery.

The established role of ATM kinase in post-IR double-strand break repair and checkpoint function underlies the DNA repair deficient- and IR-sensitive phenotype observed in AT patients.

These include a number of proteins that are involved in DNA break repair and checkpoint signaling, such as the MRX (Mre11, Rad50, Xrs2) complex, the Ku70/ 80 heterodimer, and the Tel1/ATM protein kinase (Shore and Bianchi 2009; Wellinger and Zakian 2012).

Although some Palestinian militants had called for protesters to break through Israeli checkpoints into Jerusalem today, that did not occur.