Finally, accurate prediction of NESs has been difficult because of the breadth and simultaneously, the insufficient coverage of the NES consensus.
Furthermore, the correlation between ω and betweenness remains significant when protein length and expression level and breadth are simultaneously controlled for (ρ = −0.037, P = 0.028; supplementary table S1, Supplementary Material online).
An HIV antibody achieves potency and breadth by binding simultaneously to two conserved glycans on the viral envelope protein.
This approach can fulfill two objectives, First, through the Kano model with the Fuzzy mode, it will not only discriminate out options for the required attributes in much more breadth but also simultaneously render the discretions on the linguistic implications much more accurate with the aid of the ambiguous questionnaire response method.
Hence, presence of higher proportion of transmembrane protein in human disease category makes it evident that tissue expression breadth and transmembrane transport simultaneously influence the evolutionary rates of SHD, SPD, and ND genes.
The correlation between ω and closeness remains significant when the effects of expression level and breadth, and protein length, are simultaneously controlled for (ρ = −0.061, P = 0.013).
Furthermore, these correlations remain significant when expression level, expression breadth, and protein length are simultaneously controlled for (degree: ρ = −0.038, P = 0.029; betweenness: ρ = −0.042, P = 0.014).
In this way, it is possible to simultaneously capture the breadth of the problem as well as focusing on its key aspects.
To determine whether immunization with multiple HAs simultaneously could expand the breadth of the neutralizing antibody response without significant loss of magnitude, a combination of 10 HA DNA vaccine immunogens was administered IM at proportionally lower concentration (1.5 µg per immunogen) into groups of 10 mice (see Materials and Methods).
