Our objective was to characterize studies addressing management of OA-related pain with respect to the breadth of interventions, trial duration and size, outcome measures, and funding sources.
However, these data reflect a complex interplay of contributing factors including: the breadth of the national trial portfolio; variation in activation of trials between centres and networks; difficulties investigating rare cancers and changing attitudes to consent and participation among young people.
The two-stage recruitment process, while useful in providing depth and breadth of information about trial participants and non-participants, excluded eligible individuals who were not interested or did not consent to the initial health survey.
A limitation of this paper is that it utilises a two-step recruitment process which, while useful in providing depth and breadth of information about trial participants and non-participants, excludes eligible individuals who were not interested or did not consent into the initial health survey.
The evidence we report is based on literature representing a breadth of scholarly paradigms including clinical trials, cross sectional population based studies, expert narrative reviews, randomized controlled clinical trials, and systematic reviews.
The handlebars were so wide and keeping me so upright that on my first couple of trial rides, I felt like a sailboat sail, my body's breadth working against me.
As a preliminary step, we chose to report and synthesize the literature broadly given the breadth of research paradigms and limited controlled trials amenable to systematic review.
Our simulation will help in the design of clinical trials in which the breadth of the response is being measured, by allowing a calculation for the minimum amount of blood that needs to be collected.
The breadth of this network reflects the complexity of each trial, requiring motor responses based on judgements of compound visual stimuli according to spatial and lexical information.
33 34 The search terms spanned the breadth of exercise, lifestyle and physical activity descriptors and included trial and intervention specific terms.
Our first conserved region vaccines HIVconsv employed clade alternating consensus sequences and showed promise in the initial clinical trials in terms of magnitude and breadth of elicited CD8+ T-cells.
