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It is probable then, that there are differences in selection on protein sequences of males and females independent of the breadth of tissue expression.
To examine the breadth of tissue expression of genes represented by the top 100 ranked clones, we mined the summary SAGE expression data from the Cancer Gene Anatomy Project http://cgap.nci.nih.gov/.
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Therefore, it is evident from our analysis that the interaction term of tissue expression breadth and transmembrane transport may influence the evolutionary rates of SHD, SPD, and ND genes.
In this study, we identified the importance of two distinct network perturbation models and the interaction term of tissue expression breadth and transmembrane transport (three out of the six predictors) on protein evolutionary rates except number of phenotypic defects and gene expression levels.
We describe a computational pipeline that uses microarray data to assess the level of expression and breadth of tissue profiles for transcripts with distinct first exons regulated by alternative promoters.
Both overall levels of replication and breadth of tissue tropism may be positively correlated with virulence.
We use two measures of expression: breadth of expression (the number of tissues in which a gene was expressed) and maximum expression level among tissues (the highest value of expression of a gene among tissues).
TE gene fractions and GL were compared with the overall level of gene expression and the breadth of expression across tissues.
The microarray expression data described above were used to calculate three measurements of gene expression: peak expression (PE), breadth of expression (BE) and tissue-specificity (TS).
A recent study shows that genes' breadth of expression in tissues is positively correlated with the expression level of the genes [ 24].
Moreover, the existence of a significant correlation between tissue expression breadth and the number of transmembrane helices (Transmembrane helices/protein ρExpression breadth = −0.122, P = 2.60 × 10−, n = 334) suggests that tissue expression breadth and transmembrane transport may simultaneously affect protein evolutionary rates (fig. 5).
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